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Index  »  Projects  »  phpMyEdit  »  Forum  »  Novartis Links with UK's Dunad in $1.3 Billion Protein Degra

phpMyEdit General     Novartis Links with UK's Dunad in $1.3 Billion Protein Degra
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upamfva     Joined: 05 May 2021   Posts: 918  
Post Posted: 2021-11-05 04:45
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Novartis Links with UK's Dunad in $1.3 Billion Protein Degradation Deal




Novartis has forged a collaboration with U.K.-startup Dunad Therapeutics to develop next-generation targeted protein-degradation therapies in a deal valued at up to $1.3 billion.To get more novartis news , you can visit shine news official website.

Dunad, which is based in Cambridge, England, emerged from stealth mode in March of this year, backed by the financial strength of Epidarex Capital. Dunad’s small molecule platform prompts the degradation of disease-causing proteins by modifying the target using mono-valent small molecules. Novartis is banking on Dunad’s claims that its novel approach is “fully tuneable to be exquisitely selective and underpinned by a target-class agnostic mechanism of action that is distinct from other targeted protein degradation technologies.” The small U.K. company believes its platform has the potential to develop orally bioavailable and CNS-accessible degrader therapeutics that can “significantly expand the frontiers of protein degradation targets.”

With Novartis, Dunad will apply its platform to generate novel covalent and targeted protein-degrading small molecule drugs focusing on up to four drug targets. Dunad will be responsible for the development of the assets until lead optimization. For its part, Novartis will contribute target and ligand knowledge. The Swiss pharma giant will also provide Dunad with access to unique assays and models and provide full funding for the project. Novartis will have an exclusive option to develop and commercialize any products that result from the agreement.

Under the terms of the deal, Novartis will provide Dunad with $24 million in an upfront payment and equity investment. Dunad will also be eligible for milestone payments that could climb to as much as $1.3 billion.

The protein degradation field has deepened with more companies investing resources into this approach. Companies like PhoreMost and Kymera Therapeutics have built a pipeline around the field. Earlier this year, Pfizer struck a $1 billion deal with Connecticut-based Arvinas to develop and commercialize its PROTAC estrogen receptor protein degrader. With the Dunad deal, Novartis will carve out its own stake with the intriguing modality.Patrick Gunning, Ph.D., co-founder and acting chief executive officer and chief scientific officer of Dunad, expressed his excitement about the partnership with Novartis.

“This deal highlights the clear benefits our platform promises for the development of next-generation targeted protein degrader therapeutics. We are confident that with our approach of inducing degradation via direct modulation of target proteins with mono-valent small molecules, we can significantly expand the boundaries of targeted protein degraders as a therapeutic modality,” Gunning said in a statement.

Diana Kraskouskaya, Ph.D., co-founder and chief operating officer of Dunad, noted that the collaboration with Novartis is a significant milestone for the young company. She said the partnership will allow the company to “rapidly expand the impact of our platform technology to additional target classes and therapeutic areas, beyond Dunad’s own internal target pipeline.” Kraskouskaya added that Dunad is committed to advancing its pipeline to tackle previously intractable targets.

 
Goldyy     Joined: 08 Nov 2020   Posts: 79  
Post Posted: 2022-06-10 23:48
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denisbeta     Joined: 25 Aug 2023   Posts: 1992  
Post Posted: 2023-08-25 21:35
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https://bloghealthy.press/o-caps/me/v2/?geo=103371&flow_id=tjjmlc6ekt&click_id=o2CBEvyPvb&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=7041&lp=9594

Prostamid [ME]
https://bloghealthy.press/prostamid/me/blog/?click_hash=sS7G7NZOMb&flow_hash=p0lzy1swja&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=7043
https://bloghealthy.press/prostamid/me/v1/?geo=103371&flow_id=p0lzy1swja&click_id=sS7G7NZOMb&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=7043&lp=9596

https://twitter.com/denisyakovlev68/status/1631940644406009856
https://twitter.com/denisyakovlev68/status/1631938259428298755

https://bm.denisyakovlev.ru/2023/03/blog-post_4.html
https://seocheki.net/outlink.php?url=bm.denisyakovlev.ru/2023/03/blog-post_4.html
https://archive.ph/sBA1X

Hypertea [ME]
https://bloghealthy.press/hypertea/me/blog/?click_hash=5RorZgKFUQ&flow_hash=34pdm5teop&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=7042
https://bloghealthy.press/hypertea/me/v1/?geo=103371&flow_id=34pdm5teop&click_id=5RorZgKFUQ&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=7042&lp=9595

25.02
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=30610
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=30405
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=31333
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=31020
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=30327
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=30114&pid=43584
http://www.ivedu.ru/forum/viewthread.php?forum_id=7&thread_id=1257&pid=3153
http://www.ivedu.ru/forum/viewthread.php?forum_id=15&thread_id=869
http://www.ivedu.ru/forum/viewthread.php?forum_id=7&thread_id=358
http://www.ivedu.ru/forum/viewthread.php?forum_id=18&thread_id=30971

+
https://boi.instgame.pro/forum/index.php?topic=22244.0
https://boi.instgame.pro/forum/index.php?topic=22324.0
https://boi.instgame.pro/forum/index.php?topic=21894.0
https://boi.instgame.pro/forum/index.php?topic=21940.0
https://boi.instgame.pro/forum/index.php?topic=22408.0
https://boi.instgame.pro/forum/index.php?topic=22266.0
https://boi.instgame.pro/forum/index.php?topic=22339.0
https://boi.instgame.pro/forum/index.php?topic=22409.0
https://boi.instgame.pro/forum/index.php?topic=22419.0
https://boi.instgame.pro/forum/index.php?topic=22214.15
https://boi.instgame.pro/forum/index.php?topic=22216.15
https://boi.instgame.pro/forum/index.php?topic=22137.0
https://boi.instgame.pro/forum/index.php?topic=22267.0
https://boi.instgame.pro/forum/index.php?topic=22326.0
https://boi.instgame.pro/forum/index.php?topic=22188.0
https://boi.instgame.pro/forum/index.php?topic=22440.0
https://boi.instgame.pro/forum/index.php?topic=22282.0
https://boi.instgame.pro/forum/index.php?topic=22158.0
https://boi.instgame.pro/forum/index.php?topic=22010.0
https://boi.instgame.pro/forum/index.php?topic=22296.0
https://boi.instgame.pro/forum/index.php?topic=22194.0
https://boi.instgame.pro/forum/index.php?topic=22513.0
https://boi.instgame.pro/forum/index.php?topic=22497.0
https://boi.instgame.pro/forum/index.php?topic=22504.0
https://boi.instgame.pro/forum/index.php?topic=22478.0
https://boi.instgame.pro/forum/index.php?topic=22492.0
https://boi.instgame.pro/forum/index.php?topic=22469.0
https://boi.instgame.pro/forum/index.php?topic=14088.0
https://boi.instgame.pro/forum/index.php?topic=22025.0
https://boi.instgame.pro/forum/index.php?topic=22048.0
https://boi.instgame.pro/forum/index.php?topic=21974.0
https://boi.instgame.pro/forum/index.php?topic=22083.0
https://boi.instgame.pro/forum/index.php?topic=21895.0
https://boi.instgame.pro/forum/index.php?topic=22257.0
https://boi.instgame.pro/forum/index.php?topic=21939.0
https://boi.instgame.pro/forum/index.php?topic=21983.0

https://www.linkmaximus.org/compare/thai-shop.store/vs/50discount-sale.com
https://www.linkmaximus.org/recent
https://www.linkmaximus.org/domain/thai-shop.store
https://www.linkmaximus.org/domain/50discount-sale.com

1.03 max
http://dom-nam.ru/index.php/forum/razdel-predlozhenij/11581-prikolnye-audio-pozdravleniya

Sex Essence Tablet
http://go.billion-online.ru/page/f85760b0f8348efe39fb73cc525ff5646fd1d0f4/
https://twitter.com/denisyakovlev68/status/1633132141176320002
https://sp-web.search.auone.jp/search?q=site%3Athai-shop.store


http://blog.denisyakovlev.com/2023/03/blog-post_7.html
https://seocheki.net/outlink.php?url=blog.denisyakovlev.com/2023/03/blog-post_7.html
https://archive.ph/NPYUH


https://twitter.com/denisyakovlev68/status/1631614711367102466
https://twitter.com/denisyakovlev68/status/1631615499040702464

http://www.loveplanet.ru/?affiliate_id=1254
http://12lm.di.xsl.pt
https://backlinks.ssylki.info/site/12lm.di.xsl.pt
https://ssylki.info/site/12lm.di.xsl.pt
https://seocheki.net/outlink.php?url=backlinks.ssylki.info/site/12lm.di.xsl.pt
https://seocheki.net/outlink.php?url=ssylki.info/site/12lm.di.xsl.pt
https://twitter.com/denisyakovlev68/status/1633159692514914326

Hemocure [VN]
https://beautybesthealth.asia/meta/hemocure/vn/v1/?geo=36864&flow_id=ebm7s9e56d&click_id=14j8NSDwY5&sub1=sub1&sub2=sub2&sub3=sub3&sub4=sub4&sub5=sub5&facebook=&pl=&lp=9601

+
https://seocheki.net/outlink.php?url=http%3A%2F%2Fwww.figarohair.ru%2Fconf%2Fviewtopic.php%3Ff%3D11%26t%3D9804
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?t=7998
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=7&t=8499
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=9374&p=21842
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8706
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=9699
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=53
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8269
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=9015
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https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8757
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8667
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8640
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8597
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=10048
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=10047
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=7&t=4631
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=4013&start=10
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=8882
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=4689
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=10046
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=10035
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=10016
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=10011
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=9932
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=3909
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=3&t=3680
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8166
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=3&t=3896
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=12&t=6199
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=6&t=7498
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6913
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=3&t=943
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=6072
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6834
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=7136
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=7&t=4831
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=3&t=9702
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=5886
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=10&t=8132
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6942
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=7329
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=5&t=7514
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?p=22977
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=11&p=22989
https://seocheki.net/outlink.php?url=http://www.figarohair.ru/conf/viewtopic.php?f=7&t=7843


8.03
http://www.figarohair.ru/conf/viewtopic.php?f=7&t=7843
http://www.figarohair.ru/conf/viewtopic.php?f=11&p=22989
http://www.figarohair.ru/conf/viewtopic.php?p=22977
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=7514
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=7329
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6942
http://www.figarohair.ru/conf/viewtopic.php?f=10&t=8132
http://www.figarohair.ru/conf/viewtopic.php?f=3&t=941
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=5886
http://www.figarohair.ru/conf/viewtopic.php?f=3&t=9702
http://www.figarohair.ru/conf/viewtopic.php?f=7&t=4831
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=7136
http://www.figarohair.ru/conf/viewtopic.php?f=12&t=9869
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6596&p=15263
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=935
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6834
http://www.figarohair.ru/conf/viewtopic.php?f=10&t=6072
http://www.figarohair.ru/conf/viewtopic.php?f=3&t=943
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=6913
http://www.figarohair.ru/conf/viewtopic.php?f=6&t=7498
http://www.figarohair.ru/conf/viewtopic.php?f=12&t=6199
http://www.figarohair.ru/conf/viewtopic.php?f=3&t=3896
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8166
http://www.figarohair.ru/conf/viewtopic.php?f=3&t=3680
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=4492
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=9804
http://www.figarohair.ru/conf/viewtopic.php?t=7998
http://www.figarohair.ru/conf/viewtopic.php?f=7&t=8499
http://www.figarohair.ru/conf/viewtopic.php?f=11&t=9374&p=21842
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8706
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=9699
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=53
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8269
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=9015
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8831
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8767
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8757
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8667
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8640
http://www.figarohair.ru/conf/viewtopic.php?f=5&t=8597

555

 
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